Then it is very unlikely a missing codec issue. Close any video & VR apps you have running.
Press the Windows key and type codec, this should bring up Codec Tweak Tool if you have k-Lite installed. Run it.
Then
Setting > Backup > Apply & Close and select a place to store it.
Back to Settings > Reset > Apply and close.
Check if the issue is fixed.
If not, close any video & VR apps you have running again.
Go back to the Codec Tweak Tool.
Configuration > DirectShow Filters > LAV Video Decoder > Top right section.
Make sure HEVC and H264 are both checked.
Hardware Acceleration > Hardware Decoder to use > DXVA2 Copy-Back should be the default.
Change DXVA2 Copy-Back to CUVID > Apply.
Check if this fixed the issue.
If still not, follow the previous steps again and try DXVA2 Native.
Just in case, check the dropdown menu Hardware Device to use if there are any other listed than 2x your GTX1080Ti. If there is, select your 1080
If you are still having issues, can you give me an overview of your monitors connected to your system? Resolutions, Refresh rates, how they are connected, HDMI, DP, any adapters used, etc? And the exact model of your graphics card. If you know the EAN code of the card that's even better!